A Novel Technique for Amniotic Membrane Transplantation in Patients with Acute Stevens-Johnson Syndrome

Kelly N Ma; Aristomenis Thanos; James Chodosh; Ankoor S Shah; Iason S Mantagos

doi:10.1016/j.jtos.2015.07.002

A Novel Technique for Amniotic Membrane Transplantation in Patients with Acute Stevens-Johnson Syndrome

Ocul Surf. 2016 Jan;14(1):31-6. doi: 10.1016/j.jtos.2015.07.002. Epub 2015 Sep 24.

Authors

Kelly N Ma¹, Aristomenis Thanos², James Chodosh², Ankoor S Shah³, Iason S Mantagos⁴

Affiliations

¹ Department of Ophthalmology, Boston University Medical Center, Boston University School of Medicine, Boston, MA, USA.
² Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
³ Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
⁴ Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: jason.mantagos@childrens.harvard.edu.

PMID: 26387869
DOI: 10.1016/j.jtos.2015.07.002

Abstract

Cryopreserved amniotic membrane (AM) transplantation is an emerging technique that is becoming the gold standard for the management of acute Stevens-Johnson syndrome (SJS) and its more severe variant, toxic epidermal necrolysis (TEN). We describe a novel surgical technique utilizing a single, large sheet of AM (5 x 10 cm) and a custom-made forniceal ring, which facilitates AM placement. Our technique is easy to use and minimizes suturing and manipulation of ocular tissues, resulting in decreased operative time. This technique may be applied in the management of multiple ocular surface disease processes, including chemical or thermal burns, severe ocular graft versus host disease (GVHD), and other autoimmune diseases.

Keywords: Stevens-Johnson syndrome; amniotic membrane; cryopreserved amniotic membrane; ocular surface; transplantation.

Publication types

Review

MeSH terms

Acute Disease
Amnion / transplantation*
Humans
Ophthalmologic Surgical Procedures / methods*
Stevens-Johnson Syndrome / surgery*