Posterior Reversible Encephalopathy Syndrome in Early-Stage Breast Cancer

Breast J. 2015 Nov-Dec;21(6):674-7. doi: 10.1111/tbj.12502. Epub 2015 Sep 19.

Abstract

Wider use of chemotherapy and targeted agents can be associated with posterior reversible encephalopathy syndrome (PRES). This syndrome is most commonly found in metastatic adenocarcinoma treated with platinum-based analogs and is managed with cessation of the precipitating medication. We present the first case of PRES in early-stage breast cancer and discuss the further management of this condition. Recognition of this condition and correction of identifiable precipitating factor including cessation of relevant medications remains important in its management.

Keywords: early-stage breast cancer; platinum chemotherapy; posterior reversible encephalopathy syndrome.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / pathology*
  • Carboplatin / administration & dosage
  • Docetaxel
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Staging
  • Posterior Leukoencephalopathy Syndrome / chemically induced*
  • Posterior Leukoencephalopathy Syndrome / diagnosis
  • Taxoids / administration & dosage
  • Trastuzumab / administration & dosage

Substances

  • Taxoids
  • Docetaxel
  • Carboplatin
  • Trastuzumab