Abstract
Association between genetic variants of the reelin (RELN) gene and the risk for developing Alzheimer's disease (AD) was examined in a sample of 432 patients and 308 controls. Single marker and haplotype analyses revealed that the strongly linked rs528528 and rs607755 polymorphisms are associated with AD risk in a gender specific manner. Among men, but not in women the rs528528 T/T and rs607755 A/A genotypes were significantly associated with the susceptibility to AD.
Keywords:
Alzheimer's disease; Association study; Reelin (RELN).
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Aged, 80 and over
-
Alzheimer Disease / diagnosis*
-
Alzheimer Disease / genetics*
-
Cell Adhesion Molecules, Neuronal / genetics*
-
Extracellular Matrix Proteins / genetics*
-
Female
-
Genetic Association Studies / methods*
-
Genetic Markers / genetics
-
Genetic Variation / genetics*
-
Genotype
-
Haplotypes
-
Humans
-
Male
-
Middle Aged
-
Nerve Tissue Proteins / genetics*
-
Polymorphism, Single Nucleotide / genetics
-
Reelin Protein
-
Serine Endopeptidases / genetics*
-
Sex Characteristics*
Substances
-
Cell Adhesion Molecules, Neuronal
-
Extracellular Matrix Proteins
-
Genetic Markers
-
Nerve Tissue Proteins
-
Reelin Protein
-
RELN protein, human
-
Serine Endopeptidases