Genetic analysis of the RELN gene: Gender specific association with Alzheimer's disease

Psychiatry Res. 2015 Dec 15;230(2):716-8. doi: 10.1016/j.psychres.2015.09.021. Epub 2015 Sep 13.

Abstract

Association between genetic variants of the reelin (RELN) gene and the risk for developing Alzheimer's disease (AD) was examined in a sample of 432 patients and 308 controls. Single marker and haplotype analyses revealed that the strongly linked rs528528 and rs607755 polymorphisms are associated with AD risk in a gender specific manner. Among men, but not in women the rs528528 T/T and rs607755 A/A genotypes were significantly associated with the susceptibility to AD.

Keywords: Alzheimer's disease; Association study; Reelin (RELN).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / genetics*
  • Cell Adhesion Molecules, Neuronal / genetics*
  • Extracellular Matrix Proteins / genetics*
  • Female
  • Genetic Association Studies / methods*
  • Genetic Markers / genetics
  • Genetic Variation / genetics*
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Reelin Protein
  • Serine Endopeptidases / genetics*
  • Sex Characteristics*

Substances

  • Cell Adhesion Molecules, Neuronal
  • Extracellular Matrix Proteins
  • Genetic Markers
  • Nerve Tissue Proteins
  • Reelin Protein
  • RELN protein, human
  • Serine Endopeptidases