Strategies for improving the repair of focal cartilage defects

Nanomedicine (Lond). 2015;10(18):2893-905. doi: 10.2217/nnm.15.119. Epub 2015 Sep 7.

Abstract

Articular cartilage, together with skin, was predicted to be one of the first tissues to be successfully engineered. However cartilage repair remains nowadays still elusive, as we are still not able to overcome the hurdles of creating biomaterials corresponding to the native properties of the tissue, and which operate in joints environment that is not favorable for regeneration. In this review, we give an overview of the outcome of current cartilage treatment techniques. Furthermore we present current research strategies for improving cartilage tissue engineering.

Keywords: ACI; AMIC; MACI; cartilage repair; hydrogel; microfracture; repair; scaffold.

Publication types

  • Review

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Biomechanical Phenomena
  • Cartilage, Articular / injuries
  • Cartilage, Articular / physiology*
  • Cartilage, Articular / surgery
  • Drug Delivery Systems / methods
  • Humans
  • Regeneration*
  • Tissue Engineering / methods*
  • Tissue Scaffolds / chemistry*

Substances

  • Biocompatible Materials