The complete genome sequence of a high pristinamycin-producing strain Streptomyces pristinaespiralis HCCB10218

J Biotechnol. 2015 Nov 20:214:45-6. doi: 10.1016/j.jbiotec.2015.09.010. Epub 2015 Sep 14.

Abstract

Streptomyces pristinaespiralis produces the streptogramin-like antibiotic pristinamycin, which is a mixture of two structurally different components: pristinamycin I (PI) and pristinamycin II (PII). Herein, we report the complete genome sequence of a high pristinamycin-producing strain HCCB10218 (8.5 Mb) obtained by using PacBio RSII combined with Illumina HiSeq 2500 sequencing system. The genome sequence presented here provides clues for the mechanism underlying the higher pristinamycin production of HCCB10218.

Keywords: Genome sequence; Pristinamycin; Streptomyces pristinaespiralis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Bacterial / analysis
  • DNA, Bacterial / genetics
  • Genome, Bacterial / genetics*
  • Pristinamycin / metabolism*
  • Sequence Analysis, DNA
  • Streptomyces / genetics*
  • Streptomyces / metabolism*

Substances

  • DNA, Bacterial
  • Pristinamycin

Associated data

  • GENBANK/CP011340