Abstract
A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein-ligand docking studies. The asymmetric synthesis of a series of these compounds incorporating different nucleobases has been efficiently completed starting from 1,4-cyclohexanedione.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bridged Bicyclo Compounds / chemical synthesis*
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Bridged Bicyclo Compounds / chemistry
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Crystallography, X-Ray
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Cyclohexanones / chemistry*
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Heptanes / chemical synthesis*
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Heptanes / chemistry
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Stereoisomerism
Substances
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1,4-cyclohexanedione
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Bridged Bicyclo Compounds
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Cyclohexanones
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Heptanes
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Nucleosides