Body composition, maximal aerobic performance and inflammatory biomarkers in endurance-trained athletes

Abstract

This study was designed to examine the relationships between body composition, cardiorespiratory fitness and simultaneously measured inflammatory parameters in endurance-trained athletes. In 20 well-trained rowers (19·0 ± 2·9 years; 185·6 ± 4·8 cm; 85·7 ± 10·8 kg; 17·1 ± 5·1% body fat; maximal oxygen consumption [VO₂ max]: 63·9 ± 8·5 ml min^-1 kg^-1 ), body composition was measured by dual-energy X-ray absorptiometry and cardiorespiratory fitness by direct VO₂ max test. Twelve inflammatory factors [interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10, vascular endothelial growth factor, interferon-gamma (IFN-γ), tumour necrosis factor-alpha, IL-1α, IL-1β, monocyte chemoattractant protein-1 (MCP-1), epidermal growth factor (EGF)] were analysed from serum samples. Serum IFN-γ was related (P<0·05) to fat-free mass (FFM) (r = -0·56) and muscle mass (r = -0·50). The stepwise regression analysis showed that IFN-γ explained 27·5%, and IFN-γ and IL-6 together explained 39·8% of the variability of FFM, while IFN-γ explained 21·1%, and IFN-γ together with EGF explained 36·6% of the variability of muscle mass in male rowers. Serum IL-8 (r = -0·65) and VEGF (r = -0·48) correlated (P<0·05) with VO₂ max kg^-1 . Serum IL-8 explained 38·5% of the variability of VO₂ max kg^-1 . Significant correlations were also found among several inflammatory parameters, indicating that various inflammatory cytokines act on the body as an ensemble. In conclusion, this cross-sectional study in endurance-trained male rowers showed that FFM and muscle mass were negatively correlated with serum IFN-γ level, whereas cardiorespiratory fitness was negatively related to serum IL-8 level.

Keywords: body composition; inflammatory profile; maximal aerobic performance; rowers.