Nano-Aggregates of Doxorubicin-Conjugated Methoxy Poly(ethylene glycol)-b-Carboxymethyl Dextran Copolymer

J Nanosci Nanotechnol. 2015 Aug;15(8):5566-70. doi: 10.1166/jnn.2015.10466.

Abstract

Block copolymer composed of carboxymethyl dextran (CMDex) and methoxy poly(ethylene glycol) (MPEG) (abbreviated as CMDexPEG) was synthesized and doxorubicin (DOX) was conjugated with carboxyl groups of CMDexPEG. DOX-conjugated CMDexPEG block copolymer formed nanoparticles in water with sizes less than 100 nm. DOX-conjugated nanoparticles enhanced DOX delivery to the DOX-resistant CT26 cells and showed higher anticancer activity in vitro. DOX-conjugated nanoparticles inhibited growth of CT26 solid tumor at tumor-bearing mouse model study. In near infrared (NIR)-dye study, nanoparticles were retained in the tumor tissues for a longer period.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / chemistry
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Colorectal Neoplasms / drug therapy*
  • Colorectal Neoplasms / pathology
  • Dextrans / chemistry*
  • Diffusion
  • Dose-Response Relationship, Drug
  • Doxorubicin / administration & dosage*
  • Doxorubicin / chemistry
  • Materials Testing
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Nanocapsules / administration & dosage
  • Nanocapsules / chemistry*
  • Nanocapsules / ultrastructure
  • Nanoconjugates / administration & dosage
  • Nanoconjugates / chemistry*
  • Nanoconjugates / ultrastructure
  • Particle Size
  • Polyethylene Glycols / chemistry*
  • Surface Properties
  • Treatment Outcome

Substances

  • Antibiotics, Antineoplastic
  • Dextrans
  • Nanocapsules
  • Nanoconjugates
  • Polyethylene Glycols
  • Doxorubicin
  • carboxymethyl dextran