Abstract
Block copolymer composed of carboxymethyl dextran (CMDex) and methoxy poly(ethylene glycol) (MPEG) (abbreviated as CMDexPEG) was synthesized and doxorubicin (DOX) was conjugated with carboxyl groups of CMDexPEG. DOX-conjugated CMDexPEG block copolymer formed nanoparticles in water with sizes less than 100 nm. DOX-conjugated nanoparticles enhanced DOX delivery to the DOX-resistant CT26 cells and showed higher anticancer activity in vitro. DOX-conjugated nanoparticles inhibited growth of CT26 solid tumor at tumor-bearing mouse model study. In near infrared (NIR)-dye study, nanoparticles were retained in the tumor tissues for a longer period.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antibiotics, Antineoplastic / administration & dosage
-
Antibiotics, Antineoplastic / chemistry
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Colorectal Neoplasms / drug therapy*
-
Colorectal Neoplasms / pathology
-
Dextrans / chemistry*
-
Diffusion
-
Dose-Response Relationship, Drug
-
Doxorubicin / administration & dosage*
-
Doxorubicin / chemistry
-
Materials Testing
-
Mice
-
Mice, Inbred BALB C
-
Mice, Nude
-
Nanocapsules / administration & dosage
-
Nanocapsules / chemistry*
-
Nanocapsules / ultrastructure
-
Nanoconjugates / administration & dosage
-
Nanoconjugates / chemistry*
-
Nanoconjugates / ultrastructure
-
Particle Size
-
Polyethylene Glycols / chemistry*
-
Surface Properties
-
Treatment Outcome
Substances
-
Antibiotics, Antineoplastic
-
Dextrans
-
Nanocapsules
-
Nanoconjugates
-
Polyethylene Glycols
-
Doxorubicin
-
carboxymethyl dextran