Common MIR146A Polymorphisms in Chinese Ankylosing Spondylitis Subjects and Controls

Zhenmin Niu; Jiucun Wang; Hejian Zou; Chengde Yang; Wei Huang; Li Jin

doi:10.1371/journal.pone.0137770

Common MIR146A Polymorphisms in Chinese Ankylosing Spondylitis Subjects and Controls

PLoS One. 2015 Sep 14;10(9):e0137770. doi: 10.1371/journal.pone.0137770. eCollection 2015.

Authors

Zhenmin Niu¹, Jiucun Wang², Hejian Zou³, Chengde Yang⁴, Wei Huang⁵, Li Jin²

Affiliations

¹ State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, No. 2005 Songhu Road, Shanghai, 200438, China; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI), No. 250 Bibo Road, Shanghai, 201203, China.
² State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, No. 2005 Songhu Road, Shanghai, 200438, China.
³ Division of Rheumatology, Huashan Hospital, Fudan University, No 12 Middle Wulumuqi Road, Shanghai, 200040, China.
⁴ Division of Rheumatology, Renji Hospital, Shanghai Jiaotong University, No 145 Middle Shandong Road, Shanghai, 200001, China.
⁵ Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI), No. 250 Bibo Road, Shanghai, 201203, China.

Abstract

Common polymorphisms of microRNA gene MIR146A were reported as associated with different autoimmune diseases, include systemic lupus erythematosus, psoriatic arthritis, asthma and ankylosing spondylitis. In this study we investigated MIR146A SNPs in Chinese people with ankylosing spondylitis. Three common SNPs: rs2910164, rs2431697 and rs57095329 were selected and genotyped in 611 patients and 617 controls. We found no association between these SNPs and ankylosing spondylitis in our samples.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Asian People
China
Female
Humans
Male
MicroRNAs / genetics*
Polymorphism, Single Nucleotide*
Spondylitis, Ankylosing / genetics*

Substances

MIRN146 microRNA, human
MicroRNAs

Grants and funding

This work was supported by grants from the Chinese National Natural Science Fund for Young Scholars (81101341), the National Basic Research Program (2014CB541801), the Science and Technology Committee of Shanghai Municipality (12DZ1942500), and National Health and Family Planning Commission (201202008).