Second trimester amniotic fluid myo-inositol concentrations in women later developing gestational diabetes mellitus or pregnancy-induced hypertension

J Matern Fetal Neonatal Med. 2016;29(14):2245-7. doi: 10.3109/14767058.2015.1081886. Epub 2015 Sep 12.

Abstract

Objective: To evaluate myo-inositol concentrations in amniotic fluid in women later developing gestational diabetes and hypertension.

Methods: A retrospective study was carried out with three groups of amniotic fluid samples (15-18 gestational weeks): 30 gestational hypertension pregnancies, 30 gestational diabetes pregnancies, and 30 normal pregnancy.

Results: A significant difference was observed in myo-inositol concentrations between the median gestational diabetes values (124.0 µmol/L, IQR 90.0-162.5) and the control group values (79.0 µmol/L, IQR 62.0-107.5), but also with gestational hypertension median values (79.0 µmol/L, IQR 67.75-92.0) (p < 0.001).

Conclusions: This study has shown that myo-inositol concentrations in amniotic fluid increased significantly in women later developing gestational diabetes compared to the control group.

Keywords: Amniotic fluid; fetal metabolism; gestational diabetes; gestational hypertension; myo-inositol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amniotic Fluid / metabolism*
  • Case-Control Studies
  • Diabetes, Gestational / metabolism*
  • Female
  • Humans
  • Hypertension, Pregnancy-Induced / metabolism*
  • Inositol / metabolism*
  • Pregnancy
  • Pregnancy Trimester, Second
  • Retrospective Studies

Substances

  • Inositol