Highly robust hydrogels via a fast, simple and cytocompatible dual crosslinking-based process

Chem Commun (Camb). 2015 Nov 7;51(86):15673-6. doi: 10.1039/c5cc05564d. Epub 2015 Sep 11.

Abstract

A highly robust hydrogel device made from a single biopolymer formulation is reported. Owing to the presence of covalent and non-covalent crosslinks, these engineered systems were able to (i) sustain a compressive strength of ca. 20 MPa, (ii) quickly recover upon unloading, and (iii) encapsulate cells with high viability rates.

MeSH terms

  • Acrylamides / chemistry
  • Acrylamides / radiation effects
  • Animals
  • Cell Line
  • Cell Survival
  • Chitosan / chemistry*
  • Chitosan / radiation effects
  • Compressive Strength
  • Glycerophosphates / chemistry
  • Glycerophosphates / radiation effects
  • Hydrogels / chemistry*
  • Materials Testing
  • Mice
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / radiation effects
  • Ultraviolet Rays

Substances

  • Acrylamides
  • Glycerophosphates
  • Hydrogels
  • Photosensitizing Agents
  • Chitosan
  • methacrylamide
  • beta-glycerophosphoric acid