[Increased expression of IL-16 in mouse skin allograft]

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Sep;31(9):1220-3.
[Article in Chinese]

Abstract

Objective: To detect the expression of interleukin 16 (IL-16) in skin allografts of recipient mice and the serum level of IL-16.

Methods: Two different mouse models of skin allografts were used: the isotransplant group (C57BL/6--C57BL/6, n=45) and the allotransplantation group (BALB/c--C57BL/6, n=45). The level of IL-16 in sera and skin graft homogenates was tested by ELISA at 1, 3, 5 and 7 days after transplantation and the expression of IL-16 mRNA in skin allografts was measured by reverse transcription PCR at the same time points.

Results: At 3, 5 and 7 days after skin transplantation, the levels of IL-16 protein and mRNA in the skin allografts and serum level of IL-16 in the allotransplantation group were significantly higher than those in the isotransplant group.

Conclusion: The expression of IL-16 is increased in the mouse skin allografts.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allografts
  • Animals
  • Interleukin-16 / biosynthesis*
  • Interleukin-16 / blood
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Skin / immunology*
  • Skin Transplantation*

Substances

  • Interleukin-16