Effect of enrofloxacin and chlorpyrifos on the levels of vitamins A and E in Wistar rats

Environ Toxicol Pharmacol. 2015 Sep;40(2):587-91. doi: 10.1016/j.etap.2015.08.019. Epub 2015 Aug 19.

Abstract

This study investigates the effects of enrofloxacin and chlorpyrifos, and their combination on vitamin A and E concentrations in the liver of rats. Results of this study indicated a reduction in the contents of vitamins A and E in the liver, which persisted for the entire period of the experiment. Vitamins A and E concentrations were slightly decreased (2-7%) in enrofloxacin-treated rats. In the group of rats intoxicated with chlorpyrifos, a significant decrease in the level of vitamin A was observed up to the 24th hour, and for vitamin E up to the 3rd day from the discontinuation of intoxication with the compounds under study. In the enrofloxacin-chlorpyrifos co-exposure group reduced vitamins A and E level was also noted. The greatest fall in vitamin A level was observed after 3h, while the contents of vitamin E decreased progressively up to the 3rd day. Changes in this group were less pronounced in comparison to the animals intoxicated with chlorpyrifos only.

Keywords: Chlorpyrifos; Enrofloxacin; Oxidative stress; Vitamin A; Vitamin E.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chlorpyrifos / toxicity*
  • Enrofloxacin
  • Fluoroquinolones / toxicity*
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Rats
  • Rats, Wistar
  • Vitamin A / analysis*
  • Vitamin E / analysis*

Substances

  • Fluoroquinolones
  • Vitamin A
  • Vitamin E
  • Enrofloxacin
  • Chlorpyrifos