Review of combined liver and kidney transplantation in children

Pediatr Transplant. 2015 Dec;19(8):820-6. doi: 10.1111/petr.12593. Epub 2015 Sep 9.

Abstract

In this review, we focused on CLKT with regard to indication, results, outcome, and future developments. PH1 is one of the most common diagnoses for adult and pediatric patients qualifying for CLKT. The other major indication for combined transplantation is ARPKD. CLKT appears to be superior to sequential liver and kidney transplantation in the majority of patients and overall results following CLKT are now good, even in small children. Clinical observations suggest that there is an immunological advantage of CLKT in comparison with isolated liver or kidney transplantation. More clinical studies are necessary to identify the best candidates for CLKT while the availability of donor organs is low.

Keywords: immunosuppression; indications; liver and kidney transplantation; outcome.

Publication types

  • Review

MeSH terms

  • Child
  • End Stage Liver Disease / complications
  • End Stage Liver Disease / surgery*
  • Graft Rejection / prevention & control
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / surgery*
  • Kidney Transplantation / methods*
  • Liver Transplantation / methods*
  • Perioperative Care / methods
  • Postoperative Complications
  • Treatment Outcome

Substances

  • Immunosuppressive Agents