Magnetic nanoparticles for magnetic drug targeting

Biomed Tech (Berl). 2015 Oct;60(5):465-75. doi: 10.1515/bmt-2015-0049.

Abstract

Nanomedicine and superparamagnetic iron oxide nanoparticles (SPIONs) are thought to have an important impact on medicine in the future. Especially in cancer therapy, SPIONs offer the opportunity of improving the effectivity of the treatment and reduce side effects by magnetic accumulation of SPION-bound chemotherapeutics in the tumor area. Although still some challenges have to be overcome, before the new treatment concept of magnetic drug targeting will reach the patients, substantial progress has been made, and promising results were shown in the last years.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Delayed-Action Preparations / administration & dosage*
  • Delayed-Action Preparations / chemistry
  • Delayed-Action Preparations / radiation effects
  • Humans
  • Magnetite Nanoparticles / chemistry*
  • Magnetite Nanoparticles / radiation effects
  • Magnetite Nanoparticles / ultrastructure
  • Molecular Targeted Therapy / methods*
  • Nanocapsules / chemistry*
  • Nanocapsules / radiation effects
  • Nanocapsules / ultrastructure
  • Neoplasms / drug therapy*

Substances

  • Antineoplastic Agents
  • Delayed-Action Preparations
  • Magnetite Nanoparticles
  • Nanocapsules