Factors affecting survival of medulloblastoma in children: the changing concept of management

Tai-Tong Wong; Yen-Lin Liu; Donald Ming-Tak Ho; Kai-Ping Chang; Muh-Lii Liang; Hsin-Hung Chen; Yi-Yen Lee; Feng-Chi Chang; Shih-Chieh Lin; Ting-Rong Hsu; Kuo-Wei Chen; Wei-Kang Kwang; Wu-Yu Hou; Chung-Yih Wang; Sang-Hue Yen; Wan-You Guo; Yi-Wei Chen

doi:10.1007/s00381-015-2884-2

Factors affecting survival of medulloblastoma in children: the changing concept of management

Childs Nerv Syst. 2015 Oct;31(10):1687-98. doi: 10.1007/s00381-015-2884-2. Epub 2015 Sep 9.

Authors

Tai-Tong Wong^{1

2

3}, Yen-Lin Liu^{4

5}, Donald Ming-Tak Ho⁶, Kai-Ping Chang⁷, Muh-Lii Liang⁸, Hsin-Hung Chen⁸, Yi-Yen Lee⁸, Feng-Chi Chang⁹, Shih-Chieh Lin⁶, Ting-Rong Hsu⁷, Kuo-Wei Chen¹⁰, Wei-Kang Kwang¹¹, Wu-Yu Hou¹², Chung-Yih Wang¹³, Sang-Hue Yen¹⁴, Wan-You Guo⁸, Yi-Wei Chen¹⁵

Affiliations

¹ Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. ttwong99@tmu.edu.tw.
² Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan. ttwong99@tmu.edu.tw.
³ Pediatric Neurosurgery, Department of Neurosurgery, Taipei Medical University Hospital, 252 Wuxing St, Taipei, 11031, Taiwan. ttwong99@tmu.edu.tw.
⁴ Department of Pediatrics, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
⁵ National Taiwan University and Academia Sinica, Taipei, Taiwan.
⁶ Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
⁷ Department of Pediatrics, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
⁸ Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
⁹ Department of Radiology, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan.
¹⁰ Department of Internal Medicine, Cheng Hsin General Hospital, Taipei, Taiwan.
¹¹ Department of Pathology, Cheng Hsin General Hospital, Taipei, Taiwan.
¹² Department of Radiology, Chen Hsin General Hospital, Taipei, Taiwan.
¹³ Department of Radiation Oncology, Cheng Hsin General Hospital, Taipei, Taiwan.
¹⁴ Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
¹⁵ Department of Oncology, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, 201 Sec 2 Shi Pai Rd, Taipei, 11217, Taiwan. chenyw@vghtpe.gov.tw.

PMID: 26351222
DOI: 10.1007/s00381-015-2884-2

Abstract

Medulloblastoma (MB) is a type of malignant tumor arising only in the cerebellum that was first defined by Cushing and Bailey in 1920s. In this review paper, we trace the evolution of risk stratification and the correlated changing concept of management in the past years. Outcome analysis of the hospital series of the Taipei Veterans General Hospital, Cheng Hsin General Hospital, and Taipei Medical University Hospital was performed to correlate prognostic indicators with reported studies. The purpose is to provide clues for age-specific and risk-adjusted optimal, effective, but beneficial and protective treatment strategies of these tumors in children.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adolescent
Age Factors
Cerebellar Neoplasms* / epidemiology
Cerebellar Neoplasms* / mortality
Cerebellar Neoplasms* / therapy
Child
Child, Preschool
Disease Management*
Female
Humans
Magnetic Resonance Imaging
Male
Medulloblastoma* / epidemiology
Medulloblastoma* / mortality
Medulloblastoma* / therapy
Retrospective Studies
Survival Analysis
Taiwan / epidemiology
Treatment Outcome