Abstract
Multifunctional nanomedicine integrated with both therapy and diagnostics holds vast potential in cancer treatment. We developed hybrid Fe3O4-poly(acrylic acid) (PAA) nanogels for both drug delivery and magnetic resonance imaging (MRI). Superparamagnetic Fe3O4 nanoparticles were encapsulated inside porous PAA nanogels via an in situ co-precipitation approach. With successive growth of magnetic nanoparticles, the highest magnetization saturation (M(s)) value of the Fe3O4 nanoparticles in the PAA nanogels was determined as 20 emu/g. The resulting hybrid Fe3O4-PAA nanogels showed high drug loading capacity (98%) and sustained drug release in vitro. Cytotoxicity assays and cellular imaging demonstrated that the hybrid nanogels were highly biocompatible and efficiently internalized in human neuroblastoma SH-SY5Y cells. In MRI studies, the hybrid nanogels exhibited an excellent contrast in T2 weighted imaging and a high MRI sensitivity in the tumor site.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylic Resins / chemistry*
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Acrylic Resins / therapeutic use
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Animals
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / pharmacokinetics
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Doxorubicin / administration & dosage
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Doxorubicin / pharmacokinetics
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Drug Delivery Systems*
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Ferric Compounds / chemistry*
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Ferric Compounds / therapeutic use
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Humans
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Magnetic Resonance Imaging
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Materials Testing
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Mice
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Mice, Inbred ICR
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Nanogels
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Nanoparticles / chemistry
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Nanoparticles / therapeutic use
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Neoplasms / drug therapy*
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Neoplasms / metabolism
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Neoplasms / pathology
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Polyethylene Glycols / chemical synthesis*
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Polyethylene Glycols / chemistry
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Polyethylene Glycols / therapeutic use*
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Polyethyleneimine / chemical synthesis*
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Polyethyleneimine / chemistry
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Polyethyleneimine / therapeutic use*
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Tumor Cells, Cultured
Substances
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Acrylic Resins
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Antineoplastic Agents
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Ferric Compounds
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Nanogels
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polyethylene glycol polyethyleneimine nanogel
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ferric oxide
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Polyethylene Glycols
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carbopol 940
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Doxorubicin
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Polyethyleneimine