Four new triterpenes and triterpene glycosides from the leaves of Ilex latifolia and their inhibitory activity on triglyceride accumulation

Fitoterapia. 2015 Oct:106:141-6. doi: 10.1016/j.fitote.2015.09.003. Epub 2015 Sep 5.

Abstract

Two new triterpenes (1 and 2) and two new triterpene glycosides (3 and 4), along with six known triterpenes (5-10) were isolated from the leaves of Ilex latifolia. The structures of new compounds were elucidated on the basis of NMR, HR-MS, and X-ray diffraction analysis. Compounds 4 and 5 showed potent inhibitory activity on oleic acid/palmitic acid induced triglyceride accumulation on HepG2 cells.

Keywords: Ilex latifolia; Triterpene; Triterpene glycoside.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glycosides / chemistry*
  • Hep G2 Cells
  • Humans
  • Ilex / chemistry*
  • Molecular Structure
  • Oleic Acid
  • Palmitic Acid
  • Plant Leaves / chemistry
  • Triglycerides / metabolism*
  • Triterpenes / chemistry*

Substances

  • Glycosides
  • Triglycerides
  • Triterpenes
  • Oleic Acid
  • Palmitic Acid