Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine

Daisuke Onoshima; Hiroshi Yukawa; Yoshinobu Baba

doi:10.1016/j.addr.2015.08.004

Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine

Adv Drug Deliv Rev. 2015 Dec 1:95:2-14. doi: 10.1016/j.addr.2015.08.004. Epub 2015 Sep 4.

Authors

Daisuke Onoshima¹, Hiroshi Yukawa², Yoshinobu Baba³

Affiliations

¹ Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. Electronic address: onoshima-d@nanobio.nagoya-u.ac.jp.
² ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. Electronic address: hiroshiy@med.nagoya-u.ac.jp.
³ Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14, Hayashi-cho, Takamatsu 761-0395, Japan.

PMID: 26344675
DOI: 10.1016/j.addr.2015.08.004

Abstract

A field of recent diagnostics and therapeutics has been advanced with quantum dots (QDs). QDs have developed into new formats of biomolecular sensing to push the limits of detection in biology and medicine. QDs can be also utilized as bio-probes or labels for biological imaging of living cells and tissues. More recently, QDs has been demonstrated to construct a multifunctional nanoplatform, where the QDs serve not only as an imaging agent, but also a nanoscaffold for diagnostic and therapeutic modalities. This review highlights the promising applications of multi-functionalized QDs as advanced nanosensors for diagnosing cancer and as innovative fluorescence probes for in vitro or in vivo stem cell imaging in regenerative medicine.

Keywords: Cancer diagnosis; Cationic liposomes; Cell transplantation; Cell-penetrating peptides; FRET; Microfluidic device; Quantum dots; Stem cell labeling.

Publication types

Review

MeSH terms

Animals
Diagnostic Imaging
Fluorescent Dyes / therapeutic use
Humans
Neoplasms / diagnosis*
Quantum Dots* / therapeutic use
Regenerative Medicine / methods
Stem Cell Transplantation*

Substances

Fluorescent Dyes