Cerebral gigantism and primary hypothyroidism: pleiotropy or incidental concurrence

J F Sotos; C A Romshe; E A Cutler

doi:10.1002/ajmg.1320020211

Cerebral gigantism and primary hypothyroidism: pleiotropy or incidental concurrence

Am J Med Genet. 1978;2(2):201-5. doi: 10.1002/ajmg.1320020211.

Authors

J F Sotos, C A Romshe, E A Cutler

PMID: 263438
DOI: 10.1002/ajmg.1320020211

Abstract

An 8.5-month-old baby girl had cerebral gigantism and primary hypothyroidism with generalized large muscles (the Kocher-Debré-Semelaigne syndrome). The significance of this association remains to be determined.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Cephalometry
Female
Gigantism / complications
Gigantism / genetics*
Humans
Hypothyroidism / complications
Hypothyroidism / genetics*
Infant
Phenotype
Syndrome