ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence

Mol Cell. 2015 Sep 3;59(5):713-5. doi: 10.1016/j.molcel.2015.08.010.

Abstract

Oncogene activation is usually not enough to induce cancer, but causes cells to arrest proliferation, alter chromatin structure, and increase protein secretion. In this issue of Molecular Cell, Chen et al. (2015) implicate the histone variant macroH2A.1 in the regulation of senescence.

Publication types

  • Comment

MeSH terms

  • Ataxia Telangiectasia Mutated Proteins / genetics*
  • Ataxia Telangiectasia Mutated Proteins / metabolism*
  • Cellular Senescence / genetics*
  • Cellular Senescence / physiology*
  • Histones / genetics*
  • Histones / metabolism*
  • Humans

Substances

  • Histones
  • Ataxia Telangiectasia Mutated Proteins