Emerging trends in enzyme inhibition by multivalent nanoconstructs

Org Biomol Chem. 2015 Oct 21;13(39):9894-906. doi: 10.1039/c5ob01405k.

Abstract

Multivalent nanoconstructs, extensively used for enhancing the recognition of biomolecular targets, have been recently exploited for enzyme inhibition showing interesting properties such as improvement of inhibitory potency and selectivity. We review herein the recent results highlighting the potential of multivalent nanoconstructs for the inhibition of different enzymes, and the emerging trends in the generation and identification of multivalent clusters as enzyme inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carbonic Anhydrase Inhibitors / chemistry
  • Carbonic Anhydrase Inhibitors / pharmacology
  • Carbonic Anhydrases / chemistry
  • Carbonic Anhydrases / metabolism
  • Drug Discovery / methods*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • Glycoside Hydrolases / antagonists & inhibitors
  • Glycoside Hydrolases / chemistry
  • Glycoside Hydrolases / metabolism
  • Humans
  • Models, Molecular
  • Nanostructures / chemistry*

Substances

  • Carbonic Anhydrase Inhibitors
  • Enzyme Inhibitors
  • Glycoside Hydrolases
  • Carbonic Anhydrases