The development of a short route to the API ropinirole hydrochloride

Org Biomol Chem. 2015 Nov 14;13(42):10532-9. doi: 10.1039/c5ob01739d. Epub 2015 Sep 4.

Abstract

A four-step, three-stage synthesis of the API ropinirole hydrochloride has been developed from a commercially available naphthalene derivative. The new route has half the step-count and twice the overall yield of the current manufacturing process. Key features of the synthesis are a regioselective Birch reduction and an ozonolysis with concomitant ring closure to induce the required ring contraction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Naphthylamine / chemistry*
  • Indoles / chemical synthesis*
  • Indoles / chemistry*
  • Molecular Structure
  • Naphthols / chemistry

Substances

  • Indoles
  • Naphthols
  • ropinirole
  • 1-Naphthylamine