The immunization with peptide 189-205, a derivative of serotonin receptor subtypes 1B, changes the sensetivity of adenylyl cyclase to hormones in the rat brain

K V Derkach; E A Shpakova; I I Tarasenko; O A Zharova; A O Shpakov

doi:10.1134/S1607672915040079

The immunization with peptide 189-205, a derivative of serotonin receptor subtypes 1B, changes the sensetivity of adenylyl cyclase to hormones in the rat brain

Dokl Biochem Biophys. 2015:463:225-8. doi: 10.1134/S1607672915040079. Epub 2015 Sep 3.

Authors

K V Derkach¹, E A Shpakova, I I Tarasenko, O A Zharova, A O Shpakov

Affiliation

¹ Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223, Russia.

PMID: 26335817
DOI: 10.1134/S1607672915040079

Abstract

The aim of this work was to study the effect of multiple (during 12 months) immunization of rats with BSA-conjugated peptide 189-205 corresponding to the second extracellular loop of rat HT1BR on ACSS activity in the brain of immunized animals (group HT1BR) and its regulation by hormones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenylyl Cyclases / metabolism*
Animals
Brain / drug effects*
Brain / immunology
Brain / metabolism*
Hormones / pharmacology*
Immunization*
Male
Peptide Fragments / immunology*
Rats
Rats, Wistar
Receptor, Serotonin, 5-HT1B / chemistry*
Thyroid Gland / drug effects
Thyroid Gland / immunology
Thyroid Gland / metabolism

Substances

Hormones
Peptide Fragments
Receptor, Serotonin, 5-HT1B
Adenylyl Cyclases