Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

Nobuhiro Nakai; Susumu Otsuka; Jihwan Myung; Toru Takumi

doi:10.1007/s11427-015-4891-7

Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

Sci China Life Sci. 2015 Oct;58(10):976-84. doi: 10.1007/s11427-015-4891-7.

Authors

Nobuhiro Nakai^{1

2

3}, Susumu Otsuka¹, Jihwan Myung^{1

3}, Toru Takumi^{4

5

6}

Affiliations

¹ Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.
² Graduate School of Biostudies, Kyoto University, Kyoto, 606-8501, Japan.
³ RIKEN Brain Science Institute, Wako, 351-0198, Japan.
⁴ Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8553, Japan. toru.takumi@riken.jp.
⁵ RIKEN Brain Science Institute, Wako, 351-0198, Japan. toru.takumi@riken.jp.
⁶ Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, 102-0076, Japan. toru.takumi@riken.jp.

PMID: 26335737
DOI: 10.1007/s11427-015-4891-7

Abstract

Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%-2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

Keywords: ASD model mouse; DNA methylation; copy number variations; histone modification.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autism Spectrum Disorder / genetics*
DNA Copy Number Variations
DNA Methylation
Epigenesis, Genetic*
Mice
Models, Genetic*