Cancer Metastasis: Perivascular Macrophages Under Watch

Cancer Discov. 2015 Sep;5(9):906-8. doi: 10.1158/2159-8290.CD-15-0819.

Abstract

TIE2-expressing macrophages cluster around blood vessels and sustain tumor angiogenesis. Harney and colleagues now use live imaging of mouse mammary tumors to show that these perivascular macrophages also promote the transient opening of tumor blood vessels to facilitate hematogenous cancer cell dissemination and metastasis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Capillary Permeability / drug effects*
  • Cell Movement / drug effects*
  • Female
  • Humans
  • Macrophages / metabolism*
  • Molecular Imaging*
  • Receptor, TIE-2 / metabolism*
  • Vascular Endothelial Growth Factor A / biosynthesis*
  • Vascular Endothelial Growth Factor A / pharmacology*

Substances

  • Vascular Endothelial Growth Factor A
  • Receptor, TIE-2