Ortho C-H Acylation of Aryl Iodides by Palladium/Norbornene Catalysis

Zhe Dong; Jianchun Wang; Zhi Ren; Guangbin Dong

doi:10.1002/anie.201506397

Ortho C-H Acylation of Aryl Iodides by Palladium/Norbornene Catalysis

Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12664-8. doi: 10.1002/anie.201506397. Epub 2015 Sep 1.

Authors

Zhe Dong¹, Jianchun Wang¹, Zhi Ren¹, Guangbin Dong²

Affiliations

¹ Department of Chemistry, University of Texas at Austin, 100 East 24th street, Austin, TX 78712 (USA) http://gbdong.cm.utexas.edu/
² Department of Chemistry, University of Texas at Austin, 100 East 24th street, Austin, TX 78712 (USA) http://gbdong.cm.utexas.edu/. gbdong@cm.utexas.edu.

PMID: 26333071
DOI: 10.1002/anie.201506397

Abstract

Reported herein is a palladium/norbornene-catalyzed ortho-arene acylation of aryl iodides by a Catellani-type C-H functionalization. This transformation is enabled by isopropyl carbonate anhydrides, which serve as both an acyl cation equivalent and a hydride source.

Keywords: CH activation; acylation; arenes; heterocycles; palladium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acylation
Catalysis
Iodides / chemistry*
Norbornanes / chemistry*
Palladium / chemistry*

Substances

Iodides
Norbornanes
Palladium