A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics

Tohru Yamashita; Peter C Knipe; Nathalie Busschaert; Sam Thompson; Andrew D Hamilton

doi:10.1002/chem.201503218

A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics

Chemistry. 2015 Oct 12;21(42):14657. doi: 10.1002/chem.201503218. Epub 2015 Sep 1.

Authors

Tohru Yamashita¹, Peter C Knipe¹, Nathalie Busschaert¹, Sam Thompson², Andrew D Hamilton³

Affiliations

¹ Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK).
² Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK). sam.thompson@chem.ox.ac.uk.
³ Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK). andrew.hamilton@chem.ox.ac.uk.

PMID: 26333029
DOI: 10.1002/chem.201503218

Abstract

Invited for the cover of this issue is the group of Andrew D. Hamilton and Sam Thompson at the University of Oxford (UK). The image depicts a new class of conformationally constrained β-strand mimetics mediating the interaction between two subunits of a protein that controls transcription. Read the full text of the article at 10.1002/chem.201501366.

Publication types

Duplicate Publication

MeSH terms

Biomimetics
Peptides / chemical synthesis*
Peptides / chemistry
Peptidomimetics / chemical synthesis*
Peptidomimetics / chemistry
Protein Structure, Secondary
Transcription Factors / chemistry*

Substances

Peptides
Peptidomimetics
Transcription Factors