Isoniazid@Fe2 O3 Nanocontainers and Their Antibacterial Effect on Tuberculosis Mycobacteria

Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12597-601. doi: 10.1002/anie.201505493. Epub 2015 Aug 31.

Abstract

Isoniazid-filled Fe2 O3 hollow nanospheres (INH@Fe2 O3 , diameter <30 nm, 48 wt % INH-load) are prepared for the first time and suggested for tuberculosis therapy. After dextran-functionalization, the INH@Fe2 O3 @DEX nanocontainers show strong activity against Mycobacterium tuberculosis (M.tb.) and M.tb.-infected macrophages. The nanocontainers can be considered as "Trojan horses" and show efficient, active uptake into both M.tb.-infected macrophages and even into mycobacterial cells.

Keywords: in vitro studies; isoniazid; mycobacteria; nanocontainers; tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antitubercular Agents / administration & dosage*
  • Antitubercular Agents / pharmacology*
  • Cells, Cultured
  • Ferric Compounds / chemistry*
  • Humans
  • Isoniazid / administration & dosage*
  • Isoniazid / pharmacology*
  • Macrophages / microbiology
  • Mice
  • Mycobacterium tuberculosis / drug effects*
  • Nanospheres / chemistry*
  • Nanospheres / ultrastructure
  • Tuberculosis / drug therapy

Substances

  • Antitubercular Agents
  • Ferric Compounds
  • ferric oxide
  • Isoniazid