Typhoid Fever Complicated by Hemophagocytic Lymphohistiocytosis and Rhabdomyolysis

Lemuel R Non; Rupa Patel; Amir Esmaeeli; Vladimir Despotovic

doi:10.4269/ajtmh.15-0385

Typhoid Fever Complicated by Hemophagocytic Lymphohistiocytosis and Rhabdomyolysis

Am J Trop Med Hyg. 2015 Nov;93(5):1068-9. doi: 10.4269/ajtmh.15-0385. Epub 2015 Aug 31.

Authors

Lemuel R Non¹, Rupa Patel², Amir Esmaeeli², Vladimir Despotovic²

Affiliations

¹ Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Division of Pulmonary and Critical Care, Washington University School of Medicine, St. Louis, Missouri lnon@dom.wustl.edu.
² Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Division of Pulmonary and Critical Care, Washington University School of Medicine, St. Louis, Missouri.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) and rhabdomyolysis are rare complications of typhoid fever from Salmonella enterica serovar Typhi. Herein, we describe the clinical features in a 21-year-old female from India who presented to the intensive care unit with fever, severe pancytopenia, and rhabdomyolysis.

Publication types

Case Reports

MeSH terms

Disk Diffusion Antimicrobial Tests
Drug Combinations
Drug Resistance, Bacterial
Drug Therapy, Combination
Female
Fever
Humans
India
Lymphohistiocytosis, Hemophagocytic / complications*
Lymphohistiocytosis, Hemophagocytic / drug therapy
Rhabdomyolysis / complications*
Rhabdomyolysis / drug therapy
Salmonella typhi / drug effects
Salmonella typhi / isolation & purification*
Sepsis
Sulfamethizole / therapeutic use
Treatment Outcome
Trimethoprim / therapeutic use
Typhoid Fever / complications*
Typhoid Fever / drug therapy
Young Adult

Substances

Drug Combinations
Sulfamethizole
trimethoprim sulfamethizole
Trimethoprim