[To treat or not to treat asymptomatic bacteriuria before methylprednisolone perfusion]

C Donzé; A Dinh; O Heinzlef; P Hautecoeur

doi:10.1016/j.neurol.2015.04.013

[To treat or not to treat asymptomatic bacteriuria before methylprednisolone perfusion]

Rev Neurol (Paris). 2015 Sep;171(8-9):669-73. doi: 10.1016/j.neurol.2015.04.013. Epub 2015 Aug 28.

[Article in French]

Authors

C Donzé¹, A Dinh², O Heinzlef³, P Hautecoeur⁴

Affiliations

¹ Service de médecine physique et réadaptation fonctionnelle, groupement hospitalier de l'institut catholique de Lille, rue du Grand-But, BP 249, 59462 Lomme cedex, France. Electronic address: donze.cecile@ghicl.net.
² Unité des maladies infectieuses, hôpital Raymond-Poincaré, 104, boulevard Raymond-Poincaré, 92380 Garches, France.
³ Service de neurologie, CHI de Poissy/Saint-Germain-en-Laye, CS 73082, 78303 Poissy cedex, France.
⁴ Service de neurologie, groupement hospitalier de l'institut catholique de Lille, rue du Grand-But, BP 249, 59462 Lomme cedex, France.

PMID: 26318899
DOI: 10.1016/j.neurol.2015.04.013

Abstract

The prescription of methylprednisolone for multiple sclerosis acute relapse involves sterilization of urine. An observational study was conducted to clarify the benefit of antibiotic prophylaxis in case of asymptomatic bacteriuria found before methylprednisolone. Ninety-seven patients were included; 32 patients had asymptomatic bacteriuria. Seventeen patients were treated and 15 were not. The number of urinary tract infections in the month following the methylprednisolone was the same in the two groups. The results seem in favor of a therapeutic abstention. A larger study will be performed to confirm these results and determine appropriate recommendations.

Keywords: Asymptomatic bacteriuria; Bactériurie asymptomatique; Bolus de solumédrol; Bolus solumedrol; Examen cytobactériologique des urines; Multiple sclerosis; Sclérose en plaques; Urine culture.

Publication types

Observational Study

MeSH terms

Adult
Anti-Bacterial Agents / therapeutic use*
Antibiotic Prophylaxis / statistics & numerical data*
Asymptomatic Diseases
Bacteriuria / complications
Bacteriuria / drug therapy*
Bacteriuria / microbiology
Disease Progression
Female
Gram-Negative Bacteria / isolation & purification
Gram-Negative Bacterial Infections / drug therapy
Gram-Negative Bacterial Infections / prevention & control
Gram-Positive Bacteria / isolation & purification
Gram-Positive Bacterial Infections / drug therapy
Gram-Positive Bacterial Infections / prevention & control
Humans
Immunosuppressive Agents / administration & dosage
Immunosuppressive Agents / adverse effects
Immunosuppressive Agents / therapeutic use*
Infusions, Intravenous
Male
Methylprednisolone Hemisuccinate / administration & dosage
Methylprednisolone Hemisuccinate / adverse effects
Methylprednisolone Hemisuccinate / therapeutic use*
Middle Aged
Multiple Sclerosis, Relapsing-Remitting / complications
Multiple Sclerosis, Relapsing-Remitting / drug therapy*
Treatment Outcome
Unnecessary Procedures / statistics & numerical data*
Urinary Tract Infections / epidemiology
Urinary Tract Infections / prevention & control*

Substances

Anti-Bacterial Agents
Immunosuppressive Agents
Methylprednisolone Hemisuccinate