Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes

Ekaterina N Proshkina; Mikhail V Shaposhnikov; Asiya F Sadritdinova; Anna V Kudryavtseva; Alexey A Moskalev

doi:10.1016/j.arr.2015.08.005

Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes

Ageing Res Rev. 2015 Nov;24(Pt B):218-31. doi: 10.1016/j.arr.2015.08.005. Epub 2015 Aug 28.

Authors

Ekaterina N Proshkina¹, Mikhail V Shaposhnikov¹, Asiya F Sadritdinova², Anna V Kudryavtseva², Alexey A Moskalev³

Affiliations

¹ Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Institute of Biology of Komi Science Center of Ural Branch of RAS, 167982 Syktyvkar, Russia.
² Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
³ Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia. Electronic address: amoskalev@ib.komisc.ru.

PMID: 26318059
DOI: 10.1016/j.arr.2015.08.005

Abstract

Drosophila is one of the most convenient model organisms in the genetics of aging and longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by knockout and RNAi-mediated knock-down, Drosophila also provides an opportunity to find new pro-longevity genes by driver-induced overexpression. Similar studies on other models are extremely rare. In this review, we focused on genes whose overexpression prolongs the life of fruit flies. The majority of longevity-associated genes regulates metabolism and stress resistance, and belongs to the IGF-1R, PI3K, PKB, AMPK and TOR metabolic regulation cluster and the FOXO, HDAC, p53 stress response cluster.

Keywords: Drosophila melanogaster; Overexpression; Pro-longevity genes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / physiology*
Animals
Drosophila Proteins / genetics*
Drosophila melanogaster
Humans
Longevity / genetics*

Substances

Drosophila Proteins