Dosimetric variations due to interfraction organ deformation in cervical cancer brachytherapy

Kazuma Kobayashi; Naoya Murakami; Akihisa Wakita; Satoshi Nakamura; Hiroyuki Okamoto; Rei Umezawa; Kana Takahashi; Koji Inaba; Hiroshi Igaki; Yoshinori Ito; Naoyuki Shigematsu; Jun Itami

doi:10.1016/j.radonc.2015.08.017

Dosimetric variations due to interfraction organ deformation in cervical cancer brachytherapy

Radiother Oncol. 2015 Dec;117(3):555-8. doi: 10.1016/j.radonc.2015.08.017. Epub 2015 Aug 24.

Affiliations

¹ Department of Radiation Oncology, National Cancer Center Hospital, Chuo-ku, Japan. Electronic address: kazumkob@ncc.go.jp.
² Department of Radiation Oncology, National Cancer Center Hospital, Chuo-ku, Japan.
³ Department of Radiology, Keio University School of Medicine, Shinjuku-ku, Japan.

PMID: 26316394
DOI: 10.1016/j.radonc.2015.08.017

Abstract

We quantitatively estimated dosimetric variations due to interfraction organ deformation in multi-fractionated high-dose-rate brachytherapy (HDRBT) for cervical cancer using a novel surface-based non-rigid deformable registration. As the number of consecutive HDRBT fractions increased, simple addition of dose-volume histogram parameters significantly overestimated the dose, compared with distribution-based dose addition.

Keywords: Brachytherapy; Cervical cancer; Deformable registration; Dose evaluation; Interfraction variation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brachytherapy*
Female
Humans
Radiotherapy Dosage
Uterine Cervical Neoplasms / pathology
Uterine Cervical Neoplasms / radiotherapy*