Helicobacter pylori Eradication to Eliminate Gastric Cancer: The Japanese Strategy

Gastroenterol Clin North Am. 2015 Sep;44(3):639-48. doi: 10.1016/j.gtc.2015.05.010. Epub 2015 Jul 15.

Abstract

Helicobacter pylori eradication therapy for chronic gastritis achieved world-first coverage by the Japanese national health insurance scheme in 2013, making a dramatic decrease of gastric cancer-related deaths more realistic. Combining H pylori eradication therapy with endoscopic surveillance can prevent the development of gastric cancer. Even if it develops, most patients are likely to be diagnosed at an early stage, possibly resulting in fewer gastric cancer deaths. Success with the elimination of gastric cancer in Japan could lead other countries with a high incidence to consider a similar strategy, suggesting the potential for elimination of gastric cancer around the world.

Keywords: Elimination of gastric cancer; Eradication of Helicobacter pylori; Gastric cancer; Helicobacter pylori.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Early Detection of Cancer
  • Helicobacter Infections / complications
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori*
  • Humans
  • Japan
  • Stomach Neoplasms / diagnosis
  • Stomach Neoplasms / microbiology
  • Stomach Neoplasms / prevention & control*

Substances

  • Anti-Bacterial Agents