There has been a considerable increase in the demand for artificial insemination with donor semen (A.I.D.) in Italy during the past 5 years. This study describes the 4 year experience of an infertility practice which maintains a frozen bank as its primary source of A.I.D. The overall pregnancy rate was 52.27%. There is a significant difference in pregnancies in various age groups. Our pregnancy rate was 72.2% for those women under 31 and 31.5% for those over 31.