Overview of the Lens

Prog Mol Biol Transl Sci. 2015:134:119-27. doi: 10.1016/bs.pmbts.2015.04.006. Epub 2015 May 27.

Abstract

In order to accomplish its function of transmitting and focusing light, the crystalline lens of the vertebrate eye has evolved a unique cellular structure and protein complement. These distinct adaptations have provided a rich source of scientific discovery ranging from biochemistry and genetics to optics and physics. In addition, because of these adaptations, lens cells persist for the lifetime of an organism, providing an excellent model of the aging process. The chapters dealing with the lens will demonstrate how the different aspects of lens biology and biochemistry combine in this singular refractive organ to accomplish its critical role in the visual system.

Keywords: Biochemistry; Cell biology; Development; Genetics; Lens.

Publication types

  • Review

MeSH terms

  • Aging / physiology
  • Animals
  • Humans
  • Lens, Crystalline / anatomy & histology
  • Lens, Crystalline / cytology
  • Lens, Crystalline / physiology*