OCT angiography by absolute intensity difference applied to normal and diseased human retinas

Daniel Ruminski; Bartosz L Sikorski; Danuta Bukowska; Maciej Szkulmowski; Krzysztof Krawiec; Grazyna Malukiewicz; Lech Bieganowski; Maciej Wojtkowski

doi:10.1364/BOE.6.002738

OCT angiography by absolute intensity difference applied to normal and diseased human retinas

Biomed Opt Express. 2015 Jul 6;6(8):2738-54. doi: 10.1364/BOE.6.002738. eCollection 2015 Aug 1.

Authors

Daniel Ruminski¹, Bartosz L Sikorski², Danuta Bukowska³, Maciej Szkulmowski³, Krzysztof Krawiec⁴, Grazyna Malukiewicz⁵, Lech Bieganowski⁶, Maciej Wojtkowski³

Affiliations

¹ Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Torun, Grudziadzka 5, 87-100 Torun, Poland ; both authors contributed equally.
² Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Torun, Grudziadzka 5, 87-100 Torun, Poland ; Department of Ophthalmology, Nicolaus Copernicus University, 9 M. Sklodowskiej-Curie St., 85-094 Bydgoszcz, Poland ; both authors contributed equally.
³ Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Torun, Grudziadzka 5, 87-100 Torun, Poland.
⁴ Laboratory of Intelligent Decision Support Systems, Poznan University of Technology, Piotrowo 2, 60-965 Poznań, Poland.
⁵ Department of Ophthalmology, Nicolaus Copernicus University, 9 M. Sklodowskiej-Curie St., 85-094 Bydgoszcz, Poland.
⁶ Collegium Medicum, Nicolaus Copernicus University in Torun, Jagiellońska 13-15, 85-067 Bydgoszcz, Poland.

Abstract

We compare four optical coherence tomography techniques for noninvasive visualization of microcapillary network in the human retina and murine cortex. We perform phantom studies to investigate contrast-to-noise ratio for angiographic images obtained with each of the algorithm. We show that the computationally simplest absolute intensity difference angiographic OCT algorithm that bases only on two cross-sectional intensity images may be successfully used in clinical study of healthy eyes and eyes with diabetic maculopathy and branch retinal vein occlusion.

Keywords: (110.4500) Optical coherence tomography; (170.3880) Medical and biological imaging; (170.4470) Ophthalmology; (280.2490) Flow diagnostics.