Abstract
Previous investigations suggested that lamin A/C gene (LMNA) mutations, which cause a variety of human diseases including muscular dystrophies and cardiomyopathies, alter the nuclear mechanical properties. We hypothesized that biomechanical changes may extend beyond the nucleus.
Keywords:
AFM; Young Modulus; cardiomyocytes; cardiomyopathy; cell physiology; lamin A/C; relaxation force test.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Biomechanical Phenomena
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Cell Adhesion
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Cell Nucleus / metabolism*
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Cell Shape
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Cytoskeleton / metabolism*
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Elastic Modulus
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Humans
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Lamin Type A / genetics*
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Microscopy, Atomic Force / methods*
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Models, Biological
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Mutant Proteins / metabolism
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Mutation / genetics*
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Myocytes, Cardiac / cytology*
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Myocytes, Cardiac / metabolism*
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Rats, Wistar
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Spectrum Analysis / methods*
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Tubulin / metabolism
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Viscosity
Substances
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Lamin Type A
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Mutant Proteins
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Tubulin