A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake

Chem Commun (Camb). 2015 Oct 18;51(81):14985-8. doi: 10.1039/c5cc05854f.

Abstract

Based on the protonation/deprotonation of poly(β-amino ester) (PAE), mixed-shell micelles (MSMs) with adaptive surfaces could rapidly and reversibly change surface properties to prolong circulation time in blood (pH 7.4) and enhance cellular uptake at tumor sites (pH 6.5).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacokinetics*
  • Cell Survival / drug effects
  • Doxorubicin / administration & dosage
  • Doxorubicin / blood*
  • Doxorubicin / pharmacokinetics*
  • Drug Carriers / chemistry*
  • Drug Carriers / pharmacokinetics
  • Hep G2 Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Liver Neoplasms, Experimental / drug therapy
  • Liver Neoplasms, Experimental / metabolism*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Micelles
  • Molecular Structure
  • Nanostructures / chemistry*
  • Polymers / chemistry
  • Polymers / pharmacokinetics*
  • Protons
  • Surface Properties
  • Time Factors
  • Tissue Distribution

Substances

  • Antibiotics, Antineoplastic
  • Drug Carriers
  • Micelles
  • Polymers
  • Protons
  • poly(beta-amino ester)
  • Doxorubicin