Cyanogenetic glycosides and simple glycosides from the linseed meal

Fitoterapia. 2015 Oct:106:78-83. doi: 10.1016/j.fitote.2015.08.008. Epub 2015 Aug 22.

Abstract

Three new cyanogenetic triglycosides linustatins A-C (1-3), and two new simple glycosides linustatins D and E (4 and 5) were isolated from the 70% ethanol extract of flaxseed meal (Linum usitatissimum L.). Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. All of the isolates showed moderate activities against aldose reductase and weak activities against α-glucosidase, DPP-IV, and FBPase at the same concentrations as the positive control drugs.

Keywords: Cyanogenetic glycoside; Flaxseed meal; Linum usitatissimum L.; Linustatin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Reductase / antagonists & inhibitors
  • Amygdalin / analogs & derivatives*
  • Amygdalin / isolation & purification
  • Dipeptidyl-Peptidase IV Inhibitors / isolation & purification
  • Flax / chemistry*
  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Glycosides / isolation & purification*
  • Molecular Structure
  • Plant Extracts / chemistry

Substances

  • Dipeptidyl-Peptidase IV Inhibitors
  • Glycoside Hydrolase Inhibitors
  • Glycosides
  • Plant Extracts
  • Amygdalin
  • linustatin
  • Aldehyde Reductase