Abstract
Three new phthalide derivatives, emefuranones A1, A2 and B (1-3); six new phthalane derivatives, emefuran A, B1, B2, C1, C2 and D (4-9); three new farnesylated phthalide derivatives, farnesylemefuranones A-C (10-12); xylarinol C (13); and emericelloxide (14), along with four known compounds (dustanin, sorbicillin, aspergillodiol and xylarinol A), were isolated from the culture extracts of Emericella sp. IFM57991. Structures of 1-14 were elucidated on the basis of spectroscopic analysis and chemical evidence. Compounds 4-7 and 13 showed moderate antibacterial activities against Bacillus subtilis.
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Bacillus subtilis / drug effects*
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Benzofurans / chemistry
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Benzofurans / isolation & purification
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Benzofurans / pharmacology*
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Culture Media / chemistry*
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Disk Diffusion Antimicrobial Tests
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Emericella / growth & development
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Emericella / metabolism*
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Humans
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Structure
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Phthalimides / chemistry
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Phthalimides / isolation & purification
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Phthalimides / pharmacology*
Substances
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Anti-Infective Agents
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Benzofurans
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Culture Media
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Phthalimides
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phthalide
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folpet