Complete genome sequence analysis of enterovirus 71 isolated from children with hand, foot, and mouth disease in Thailand, 2012-2014

Virus Genes. 2015 Oct;51(2):290-3. doi: 10.1007/s11262-015-1239-0. Epub 2015 Aug 25.

Abstract

The complete genomic sequences of 14 enterovirus 71 (EV71) strains isolated from children with hand, foot, and mouth disease in Thailand from 2012 to 2014 were determined and compared to enterovirus group A prototypes. Phylogenetic analysis revealed that 13 strains resembled the B5 subgroup, while one strain from a fatal case designated THA_1219 belonged to the C4 subgroup. Similarity plot and bootscan analyses suggested that THA_1219 underwent recombination in the P2 and P3 regions. Full-genome data from this work will contribute to the study of evolution dynamics of EV71.

Keywords: Enterovirus 71; Prevalence; Recombinants; Southeast Asia; Thailand.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Cluster Analysis
  • Enterovirus A, Human / classification
  • Enterovirus A, Human / genetics*
  • Enterovirus A, Human / isolation & purification*
  • Genome, Viral*
  • Hand, Foot and Mouth Disease / virology*
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Viral / genetics*
  • Recombination, Genetic
  • Sequence Analysis, DNA*
  • Sequence Homology
  • Thailand

Substances

  • RNA, Viral

Associated data

  • GENBANK/KR045291
  • GENBANK/KR045292
  • GENBANK/KR045293
  • GENBANK/KR045294
  • GENBANK/KR045295
  • GENBANK/KR045296
  • GENBANK/KR045297
  • GENBANK/KR045298
  • GENBANK/KR045299
  • GENBANK/KR045300
  • GENBANK/KR045301
  • GENBANK/KR045302
  • GENBANK/KR045303
  • GENBANK/KR045304