Metabolic Remodeling in Times of Stress: Who Shoots Faster than His Shadow?

Tobias P Dick; Markus Ralser

doi:10.1016/j.molcel.2015.08.002

Metabolic Remodeling in Times of Stress: Who Shoots Faster than His Shadow?

Mol Cell. 2015 Aug 20;59(4):519-21. doi: 10.1016/j.molcel.2015.08.002.

Authors

Tobias P Dick¹, Markus Ralser²

Affiliations

¹ Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
² Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK; The Francis Crick Institute, Mill Hill Laboratory, Mill Hill, London, NW71AA, UK. Electronic address: mr559@cam.ac.uk.

PMID: 26295959
DOI: 10.1016/j.molcel.2015.08.002

Abstract

A sudden increase in pentose phosphate pathway (PPP) activity, the fastest known cellular response to oxidative stress, protects cells through timely generation of NADPH. Originally discovered in budding yeast, Kuehne and colleagues demonstrate the conservation of this mechanism in human cells and reveal its importance for skin cells exposed to UV light.

Publication types

Comment

MeSH terms

Carrier Proteins / metabolism*
Humans
Hydrogen Peroxide / pharmacology*
Keratinocytes / drug effects*
Keratinocytes / radiation effects*
Membrane Proteins / metabolism*
Pentose Phosphate Pathway / drug effects*
Pentose Phosphate Pathway / radiation effects*
Thyroid Hormones / metabolism*

Substances

Carrier Proteins
Membrane Proteins
Thyroid Hormones
Hydrogen Peroxide