Abstract
Four dimeric acremines, bisacremines A-D (1-4), with a novel carbon skeleton and a new monomer, acremine T (5), were obtained from cultures of the soil-derived fungus Acremonium persicinum SC0105. Their structures were characterized by analysis of spectroscopic data, ECD/TDDFT computations, and X-ray diffraction. Compounds 1 and 2 exhibited weak cytotoxicity against HeLa cells, and 2 also showed modest activity against A549 and HepG2 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acremonium / chemistry*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Benzoquinones / chemistry
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Benzoquinones / isolation & purification*
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Benzoquinones / pharmacology
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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HeLa Cells
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Hep G2 Cells
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Soil Microbiology
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
Substances
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Antineoplastic Agents
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Benzoquinones
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Terpenes