Bisacremines A-D, Dimeric Acremines Produced by a Soil-Derived Acremonium persicinum Strain

J Nat Prod. 2015 Sep 25;78(9):2161-6. doi: 10.1021/np501037x. Epub 2015 Aug 21.

Abstract

Four dimeric acremines, bisacremines A-D (1-4), with a novel carbon skeleton and a new monomer, acremine T (5), were obtained from cultures of the soil-derived fungus Acremonium persicinum SC0105. Their structures were characterized by analysis of spectroscopic data, ECD/TDDFT computations, and X-ray diffraction. Compounds 1 and 2 exhibited weak cytotoxicity against HeLa cells, and 2 also showed modest activity against A549 and HepG2 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acremonium / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Benzoquinones / chemistry
  • Benzoquinones / isolation & purification*
  • Benzoquinones / pharmacology
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Soil Microbiology
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology

Substances

  • Antineoplastic Agents
  • Benzoquinones
  • Terpenes