Terpenoids from the Octocoral Sinularia gaweli

Wun-Jie Lin; Tung-Ying Wu; Tzu-Rong Su; Zhi-Hong Wen; Jih-Jung Chen; Lee-Shing Fang; Yang-Chang Wu; Ping-Jyun Sung

doi:10.3390/ijms160819508

Terpenoids from the Octocoral Sinularia gaweli

Int J Mol Sci. 2015 Aug 18;16(8):19508-17. doi: 10.3390/ijms160819508.

Authors

Wun-Jie Lin^{1

2}, Tung-Ying Wu³, Tzu-Rong Su^{4

5}, Zhi-Hong Wen⁶, Jih-Jung Chen⁷, Lee-Shing Fang⁸, Yang-Chang Wu^{9

10

11

12}, Ping-Jyun Sung^{13

14

15

16

17}

Affiliations

¹ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. abcdewq213@hotmail.com.
² National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan. abcdewq213@hotmail.com.
³ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. kuma0401@gmail.com.
⁴ Department of Beauty Science, Meiho University, Pingtung 912, Taiwan. a081002@mail.tsmh.org.tw.
⁵ Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan. a081002@mail.tsmh.org.tw.
⁶ Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
⁷ Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. jjchen@mail.tajen.edu.tw.
⁸ Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
⁹ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹⁰ School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹¹ Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹² Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.
¹³ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹⁴ National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹⁵ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.
¹⁶ Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.
¹⁷ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.

Abstract

Two eudesmane sesquiterpenoids, verticillatol (1) and 5α-acetoxy-4(14)-eudesmene-1β-ol (2) and two cembrane diterpenoids, (-)-leptodiol acetate (3) and sinulacembranolide A (4) were isolated from the octocoral Sinularia gaweli and compounds 2-4 are new isolates. The structures of new terpenoids 2-4 were elucidated by spectroscopic methods and by comparison the spectral data with those of known analogues. Terpenoid 4 was found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 marcophage cells.

Keywords: Sinularia gaweli; cembrane; eudesmane; iNOS; octocoral.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Anti-Inflammatory Agents / analysis*
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology
Diterpenes / analysis*
Diterpenes / isolation & purification
Diterpenes / pharmacology
Lipopolysaccharides / immunology
Macrophages / drug effects
Macrophages / immunology
Mice
Nitric Oxide Synthase Type II / immunology
Sesquiterpenes / analysis*
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology

Substances

Anti-Inflammatory Agents
Diterpenes
Lipopolysaccharides
Sesquiterpenes
verticillatol
Nitric Oxide Synthase Type II