Copper-catalyzed cyanation of aryl iodides with α-cyanoacetates via C-CN bond activation

Org Biomol Chem. 2015 Oct 21;13(39):9963-8. doi: 10.1039/c5ob01675d.

Abstract

A Cu(I)-catalyzed cyanation reaction of aryl iodides with α-cyanoacetates is reported herein, which uses α-cyanoacetates as the nontoxic and easy-handling CN source through copper-mediated C-CN bond cleavage. This reaction enables access to aryl nitriles with an array of functional groups on the aromatic ring in good to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Hydrocarbons, Aromatic / chemical synthesis
  • Hydrocarbons, Aromatic / chemistry*
  • Iodides / chemistry*
  • Nitriles / chemical synthesis
  • Nitriles / chemistry*

Substances

  • Acetates
  • Hydrocarbons, Aromatic
  • Iodides
  • Nitriles
  • Copper