Abstract
A Cu(I)-catalyzed cyanation reaction of aryl iodides with α-cyanoacetates is reported herein, which uses α-cyanoacetates as the nontoxic and easy-handling CN source through copper-mediated C-CN bond cleavage. This reaction enables access to aryl nitriles with an array of functional groups on the aromatic ring in good to excellent yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemistry*
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Catalysis
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Copper / chemistry*
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Hydrocarbons, Aromatic / chemical synthesis
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Hydrocarbons, Aromatic / chemistry*
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Iodides / chemistry*
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Nitriles / chemical synthesis
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Nitriles / chemistry*
Substances
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Acetates
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Hydrocarbons, Aromatic
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Iodides
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Nitriles
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Copper