Working stiff: how obesity boosts cancer risk

Lisa M Arendt; Charlotte Kuperwasser

doi:10.1126/scitranslmed.aac9446

Working stiff: how obesity boosts cancer risk

Sci Transl Med. 2015 Aug 19;7(301):301fs34. doi: 10.1126/scitranslmed.aac9446.

Authors

Lisa M Arendt¹, Charlotte Kuperwasser²

Affiliations

¹ Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
² Developmental, Molecular, and Chemical Biology Department, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA. Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA. Raymond and Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA. charlotte.kuperwasser@tufts.edu.

Abstract

Obesity promotes breast cancer by enhancing the stiffness of breast adipose tissue through changes in the extracellular matrix (Seo et al., this issue).

Publication types

Comment

MeSH terms

Adipose Tissue / metabolism*
Animals
Breast Neoplasms / etiology*
Breast Neoplasms / metabolism*
Extracellular Matrix / metabolism*
Female
Humans
Obesity / metabolism*

Grants and funding

R01 HD073035/HD/NICHD NIH HHS/United States