The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine

Chem Commun (Camb). 2015 Oct 7;51(78):14648-51. doi: 10.1039/c5cc05699c.

Abstract

Natural products are important sources of therapeutic drugs. However, it is a challenge to simplify the structure of natural products without decreasing the biological activity. Here we provide the first example of the successful simplification of an antifungal natural product. Starting from sampangine, two novel simplified scaffolds with excellent antifungal activity were discovered.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / pharmacology*
  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology
  • Biofilms
  • Biological Products / chemistry
  • Biological Products / pharmacology
  • Candida / drug effects
  • Drug Discovery*
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Naphthyridines

Substances

  • Alkaloids
  • Antifungal Agents
  • Biological Products
  • Heterocyclic Compounds, 4 or More Rings
  • Naphthyridines
  • sampangine