Enhanced cellular uptake of nanoparticles by increasing the hydrophobicity of poly(lactic acid) through copolymerization with cell-membrane-lipid components

Mariam Samadi Moghaddam; Markus Heiny; V Prasad Shastri

doi:10.1039/c5cc06397c

Enhanced cellular uptake of nanoparticles by increasing the hydrophobicity of poly(lactic acid) through copolymerization with cell-membrane-lipid components

Chem Commun (Camb). 2015 Oct 7;51(78):14605-8. doi: 10.1039/c5cc06397c.

Authors

Mariam Samadi Moghaddam¹, Markus Heiny, V Prasad Shastri

Affiliation

¹ Institute for Macromolecular Chemistry, University of Freiburg, Stefan-Meier-Str. 31, 79104 Freiburg, Germany. prasad.shastri@gmail.com.

PMID: 26287526
DOI: 10.1039/c5cc06397c

Abstract

The influence of hydrophobicity on the internalization of polymeric nanoparticles (NPs) remains poorly investigated. The hydrophobicity of poly(L-lactide) was increased by copolymerization with cell-membrane-lipid components, and this significantly enhanced the uptake of NPs up to 60% in the human cervical cancer cell line in comparison to unmodified poly(L-lactide) NPs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Membrane / metabolism
Hydrophobic and Hydrophilic Interactions
Lactic Acid / chemistry*
Membrane Lipids / metabolism*
Nanoparticles*
Polyesters
Polymerization
Polymers / chemistry*

Substances

Membrane Lipids
Polyesters
Polymers
Lactic Acid
poly(lactide)