Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes

Khachatur Julfakyan; Yevhen Fatieiev; Shahad Alsaiari; Lin Deng; Alaa Ezzeddine; Dingyuan Zhang; Vincent M Rotello; Niveen M Khashab

doi:10.3390/ijms160818283

Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes

Int J Mol Sci. 2015 Aug 6;16(8):18283-92. doi: 10.3390/ijms160818283.

Authors

Khachatur Julfakyan¹, Yevhen Fatieiev², Shahad Alsaiari³, Lin Deng⁴, Alaa Ezzeddine⁵, Dingyuan Zhang^{6

7}, Vincent M Rotello⁸, Niveen M Khashab⁹

Affiliations

¹ Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. khachatur.julfakyan@kaust.edu.sa.
² Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. yevhen.fatieiev@kaust.edu.sa.
³ Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. shahad.alsaiari@kaust.edu.sa.
⁴ Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. lin.deng@kaust.edu.sa.
⁵ Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. alaa.ezzeddine@kaust.edu.sa.
⁶ Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. zhang-chem@hotmail.com.
⁷ Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. zhang-chem@hotmail.com.
⁸ Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA. rotello@chem.umass.edu.
⁹ Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. niveen.khashab@kaust.edu.sa.

Abstract

Polydopamine-coated FeCo nanocubes (PDFCs) were successfully synthesized and tested under microwave irradiation of 2.45 GHz frequency and 0.86 W/cm(2) power. These particles were found to be non-toxic in the absence of irradiation, but gained significant toxicity upon irradiation. Interestingly, no increase in relative heating rate was observed when the PDFCs were irradiated in solution, eliminating nanoparticle (NP)-induced thermal ablation as the source of toxicity. Based on these studies, we propose that microwave-induced redox processes generate the observed toxicity.

Keywords: FeCo nanocubes; microwave radiation; nanomedicine; polydopamine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials
HeLa Cells
Humans
Indoles / chemistry*
Magnetite Nanoparticles / chemistry*
Magnetite Nanoparticles / ultrastructure
Materials Testing
Microwaves / adverse effects*
Oxidation-Reduction
Polymers / chemistry*

Substances

Biocompatible Materials
Indoles
Magnetite Nanoparticles
Polymers
polydopamine